Enrollment Comments: Quarters usually offered: Fall. Not open to students who have completed Chemistry A. Chemical thermodynamics: laws of thermodynamics, phase equilibria, chemical equilibria, equations of state.
Recommended Preparation: Chemistry or equivalent. Lecture: instrumental techniques, data analysis, error analysis, instruction in Mathematica-R. Laboratory: Mathematica-R, a symbolic programming language, is taught in the computer laboratory.
Quantum theory and spectroscopy: introduction to quantum mechanics; symmetry, molecular structure, and spectroscopy. Kinetic theory of gases, chemical kinetics, statistical mechanics, photochemistry.
Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications. Enrollment Comments: Offered concurrently with Chemistry B. Molecular orbital theory and valence bond theory; Huckel theory secular eqn. Enrollment Comments: Offered concurrently with Chemistry C.
Quarters usually offered: Winter. Principles of analytical chemistry including spectroscopy, classical techniques and separation processes. Quantitative analysis of unknowns. Introduction to instrumental analysis. Experiments in thermodynamics, spectroscopy, and electrochemistry. Synthesis and study of inorganic complexes.
Instrumental techniques such as NMR, fluorescence, Raman and laser flash photolysis are explored. Methods of data and error analysis. Synthesis of inorganic and organometallic complexes including techniques for air-sensitive materials. Instrumental characterization and study of synthesized compounds in a research-like setting. Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties. Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.
Recommended Preparation: Chemistry 1C. Study of Earth's biogeochemical cycles with respect to carbon, nitrogen, and sulfur. Introduction to the science of climate change, including effects of global warming on terrestrial and aquatic ecosystems.
Environmental impacts of fossil fuel and biofuel technologies. Chemistry of the atmosphere, hydrosphere, and lithosphere, with emphasis on ozone depletion, photochemical smog, acid rain, global ocean acidification, soil and groundwater contamination, and environmental costs of industrialized agriculture. Recommended Preparation: Chemistry C or C. Structure determination of complex organic molecules. Application of molecular biology techniques to perform mutagenesis and cloning; restriction endonucleases, PCR, plasmid purification and DNA analysis.
Protein purification and analysis methods: expression of proteins in bacterial systems. Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics and computer graphical interfaces to problems in chemistry, biochemistry, drug design and pharmacology.
Recommended Preparation: Chemistry Mechanisms of thermal, photochemical, organometallic, electrochemical asymmetric or other processes in organic chemistry. A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and steriochemical issues.
Synthetic methods and applications to natural products total syntheses involving transition metals. Recommended Preparation: Taken or concurrently enrolled in Chem A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions for building complicated molecules from scratch.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine.
This course surveys chemical methods for the production of these molecules and their application to biological problems. Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation RIP , X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules. Discussion sections using science articles to convey "how science gets done" and its limitations.
Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation. Macromolecular biosynthesis and specialized cellular processes.
A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility. Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life. Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design.
Practical computer graphics experience. Enrollment Comments: Concurrently offered with Chemistry Introduction to the structures and roles of lipids and their phase behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
Discusses the origins and evolution of the solar system and the earth, the origins and evolution of life on earth, and the possibilities for life elsewhere in the cosmos, all from the perspective of contemporary, terrain biochemistry. Recent developments aiming at engineering new biomaterials, therapeutics, nano-machines, nano-robots, alternative genetic and regulatory systems and new cellular organisms will be presented.
Combined lab and discussion course on how science works. Includes three labs on student-generated questions.
Discussions include the analysis of research papers, science controversies, how science defines new areas of "ignorance," and the observation of research group meetings. Recommended Preparation: Chemistry AL may be taken concurrently. Principles of analytical chemistry including classical techniques, spectrophotochemistry, electroanalytical techniques, and separation processes.
Focus is on well-characterized pathways from horseshoe crabs, abolones, mussels, and fish as well as others. Principles of analytical methodology, as in spectroscopy, electroanalysis, and chromatography. Applications to environmental problems, forensic and clinical analysis, and industry. Analysis of solids and surfaces. A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
Chemistry, structure and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes. Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure based drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills. Recommended Preparation: Chemistry , , or A. Medical chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmocokinetics, drug metabolism and toxicity, pharmacogenomics.
Drugs that interact with DNA and protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project. Recommended Preparation: Taken or concurrently enrolled in one of the following; Chemistry , , , or Covers the arrow pushing formalism and addresses organic reactions from this perspective. Selected topics in bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopy or properties of metal sites.
Enrollment Comments: Concurrently offered with Chemistry A. Quarters usually offered: Summer,Fall. Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.
Concurrently offered with Chemistry B. Structures of ordered crystalline solids, X-Ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis.
Bioinorganic chemistry. Enrollment Comments: Offered concurrently with Chemistry Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic and organometallic reactions and their mechanisms. Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic and organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. On a weekend try to watch a video, or listen to an au dio. Head TA: To be announced. All ques tions regarding enrollm ent i ssues.
TA office hours and d iscussion se ctions will be po sted on the. T oupadakis. Your teache r wrote both of these bo oks and they are highly rec ommended. You can find them at the UCD memorial u nion, campus booksto re. Course M aterials Laborat ory — Required. University of C alifornia Da vis.
Chemistry 2A Section A. Fall 8. Relaxat io n: During w eekends, we get together for so me garden work,. See at:. See students at their gardens:. Regrade Policy: Exams w ill be hande d back during the laboratory per iod. Please review your exam and compare to the answer. Once you l eave the laboratory class, you may. Mastery with SI un its, conversions, sc ientific no tation, and algebraic. Understand chemical bo nding as it relates t o structure s, hybridization,. Ability to read to und erstand, and interpret the period ic table and.
Basic understanding the electron and the at om as it relates to. Knowledge of the k inetic theory of gase s and use of the various gas.
Ability to solve chem ical probl ems of s olutions i nvolvi ng aqu eous. Connect the to pics to applications in daily life s ituations. Exams: Two midterm examinations wi ll be given during the regular lect ure. Exam I on Tuesday , October 16 will cover the following chapte rs:. Exam II on Thurs day , November 15 will cove r the following. Final E xam on Tue sday , December 11 at p m will be. Exam Mis sed:. Sorry, this is. A valid reason fo r their absence fo r the final written.
A passin g grade for both midterms go in g int o t he f ina l. Passing grade means, above the class aver age. Mis sin g o ne midterm and the final even w ith written va lid.
You are re sponsible for a ll of the above material,. The time and location of your 1 -. Laborat ory: hour discussion session and the 3 - hour laborato ry session. Informa tion is online. Students must complete all laboratory expe riments and. It is your responsibi lity to f inish an y misse d. This proposed schedule is subject to change, so please check back when planning each quarter's schedule. Click here to view the prerequisites for the courses. If you already have a course web page in your home directory on the Chem web server, or other location, and need a link posted for the current quarter, please email the webmaster.
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